Bob : I feel comfortable saying there are no differences in efficacy among any PPIs for the above conditions. It also has been suggested that PPIs are associated with increased rates of community-acquired pneumonia 1 and Clostridium difficile colitis. Andrea : There are no differences among PPIs except cost, so go with the cheapest. However, the cheapest is not what ends up in our sample cabinet. Mark : I agree—save your patient some cash and go for the less expensive drug.
Main Points. Make sure that any article that evaluates treatments uses equipotent dosages of the drugs being compared. As a corollary, a placebo-controlled trial should not typically change your practice; any drug comparison should be against a known effective therapy, if one exists. First is publication bias—only positive trials are usually published.
Already a member or subscriber? Log in. Interested in AAFP membership? Learn more. Reprints are not available from the authors. Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile -associated disease.
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Previous: Newsletter. Next: The Safety of Caffeine Consumption. Nov 1, Issue. From left: Dr. Mark Graber, Dr. Andrea Darby-Stewart, and Dr. Those with osteoporosis should monitor or avoid the use of PPIs. Long-term use of pantoprazole and omeprazole can worsen or increase the risk of systemic lupus erythematosus, a rare autoimmune disease.
Treatment with PPIs can increase the risk of diarrhea from Clostridium difficile infections. This risk may be higher in those who are hospitalized for a long time. PPIs can interfere with the absorption of vitamin B12 in the body, which can lead to vitamin B12 deficiency over time.
PPIs can also affect the absorption of magnesium, which can lead to low levels of magnesium in the body hypomagnesemia. Both pantoprazole and omeprazole are in Pregnancy Category C and may cause harm to an unborn baby. Consult a doctor or healthcare provider if you are pregnant or breastfeeding before using a PPI.
It is often taken as a 40 mg delayed-release tablet for up to 8 weeks. It can be taken in adults and children 5 years and older. It is also FDA approved for H. It can be taken as a 20 mg delayed-release capsule for 4 to 8 weeks in adults and children 1 year and older. Pantoprazole and omeprazole are in the same class of medications. However, they have different approved uses and side effects.
They also come in different dosages and formulations. Pantoprazole and omeprazole are both effective for GERD and erosive esophagitis. One PPI drug may be preferred over the other depending on the condition being treated and the cost of the medication. Pantoprazole and omeprazole are not recommended in pregnant women due to the risk of fetal harm. However, in some cases, the benefits may outweigh the risk. Consult a doctor if you are pregnant.
Consuming alcohol may increase certain side effects associated with pantoprazole or omeprazole. Alcohol may worsen PPI side effects, such as headache and nausea. Over-the-counter OTC omeprazole contains the same active ingredient found in prescription-strength omeprazole. This treatment course should not be taken more than once every 4 months. Since pantoprazole and omeprazole work in identical ways, they should not be taken at the same time.
They both work as PPIs to reduce the production of acid in the stomach. Taking them together could increase the risk of adverse effects. Skip to main content Search for a topic or drug. Pantoprazole vs. By Gerardo Sison, Pharm. Updated on Sep. Top Reads in Drug vs. Toujeo vs Lantus: Main Differences and S Dulera vs Advair: Main Differences and S Omeprazole and pantoprazole are safe for most people to use, with a few exceptions.
There are no adequate studies yet on either drug about the risks for women who are nursing or pregnant. While omeprazole is considered to be safe for children over the age of one year, pantoprazole can be prescribed by a healthcare provider in very specific circumstances for children five years of age and up FDA, While more research is still needed, studies have found that PPIs may be more dangerous for those living with or at risk of migraines, visual impairment, and memory problems Makunts, Since PPIs are intended for short-term use, any prolonged use of either drug could increase the risks for adverse effects or even death.
A large study found that PPI users had a greater risk of death compared to patients taking H2 blockers or no stomach acid-reducing medications at all Xie, Talk to a healthcare provider before taking either omeprazole or pantoprazole.
Do not take these drugs together as it could increase the risk of side effects. For more information about side effects and safety, you can check out the medication pamphlets for Prilosec omeprazole and Protonix pantoprazole. Last updated October 6, Written by Anna Brooks. Disclaimer If you have any medical questions or concerns, please talk to your healthcare provider.
Vitals Omeprazole and pantoprazole are popular drugs used to manage and treat conditions including chronic heartburn, gastroesophageal reflux disease GERD , and erosive esophagitis. Both drugs are types of proton pump inhibitors PPIs , a class of drugs that helps combat heartburn by suppressing acid production in the stomach.
Omeprazole and pantoprazole are safe, well-tolerated, and considered to be equally effective; however, if taken incorrectly, they can cause serious side effects. The main differences between these two medications are cost, dosage, and potential drug interactions. Learn more. Related articles. What can pantoprazole and PPIs be used for? Does omeprazole have serious drug interactions?
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